What would you recommend to help quitting venlafaxine? The withdrawals can be hellish, but a friend really wants to quit. Any advice would be appreciated.
The medical professional method would be to switch to Fluoxetine and taper that down (due to longer half life, it's hard to taper something so short lasting like velafaxine) IMO, because ''Venlafaxine indirectly affects opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes)'' you'd be best off taking a bunch of Agmatine, Magnesium glycinate & citrate & Memantine (hard to obtain, unless you know who to get it from) should help withdrawal while making it quicker. If your friend wants a sustainable and non-shitty antidepressant like any of the following (also used in combo): Moclobemide, Selegiline, Memantine (Dual uses yay!), *low* dose Tianeptine then he can contact our friendly Portuguese pharmacist friend
The memantine would be very effective to quit effexor xr, but as mentionned, you probably must get it from the friendly portuguese pharmacist ^^ check if its controlled first though since it may be prescription like in my country, but it is not controlled which means can be imported

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