I have a family member showing signs of senile dementia/Alzheimer's. Any recommendations for nootropics that what we could try to slow down or reverse the effects of memory loss?
Alyssa
Methylene blue helps in early treatment via mitochondria and cytochrome c oxidase.

Methylene blue is the most effective agents to delay senescence in normal human cells.

AD patients also have very low carnosine, so I would combine carnosine with methylene blue.

Dose however, I'm not exactly sure.
Koen
so sorry to hear from your familymember. I think (oldr) docter are to sceptical about noots so you are good here. I would go for a mix of choline, piracetam and huperzine A. All the best,
Isak
I've heard thar LSD is supposed to help, but it seems a little extreme though. The hypothesis encompasses flushing the brain with abnormal activity that will slow down the cognitive regression, somewhat like stimulation of muscle tissue.
Andrew
Large amounts of omega fatty acids (FULL SPECTRUM), from animal and plants. Apply RAW organic coconut oil for dementia/Alzheimer directly to the nape and shoulders, also eat it. Take full spectrum vitamin E, more tocotrienols the better. Take time released niacin, and probiotics.

Do not eat processed oils, canola/peanut. Reduce dietary red meat. 64oz of clean water everyday, all your minerals and electrolytes.
Maxx
Substances that increase Nitric Oxide production have profound anti-aging effects due to a decline of NO that accompanies aging. NO is called the molecule of life for a reason. So far, Agmatine & a super potent Noni (Morinda Citrifolia) plant extract (brand name Nitro FX) are the best ones i've tried. Syrian Rue has positive effects on NO also but I'm not sure how potent it is. Pro-cholinergics help reduce cognitive decline in general (choline sources such as eggs, racetams such as Noopept and acetylcholinesterase inhibitors like Huperzine A to name a few).
Stanley
Recent studies show many people with Alzheimer's benefit from DHA/fish oil. I suggest trying Brain Octane in morning coffee. Bulletproof exec has some info. You can also look at biohacking Alzheimer's by Steve Fowkes on YouTube
Robert
Turmeric Curcumin. Alzheimer's rate in India are very low because of the consumption of this in curry. You can either eat a lot of curry (which is okay by me because it's yummy!) or buy capsules. I buy 1000mg capsules from piping rock.
Bobby
Memantine lifts a layer of fog that I never know was there. I just started it for the second time, & when it kicks in, it's like you've been driving through the rain, struggling to see, & then you discover that you have windshield wipers.
Caleb
Memantine, Agmatine, Taurine-like derivatives have shown neuroprotective & B-amyloid cleansing properties. Would be good to take taurine. Curcumin + Piperine has shown promising effects on neurodegeneration. Although it doesn't last long, 7,8-dihydroxyflavone has shown remarkable & broad healing properties.
Davey
Heard one about daily ibruprofen stemming the onset of dementia/alzheimers I think about one year ago..... the irony being I cant remember
David
I saw an episode on Dr OZ where researchers discovered and were able to draw a link between taking benzos over a long period of time that can physically change the brain and is thought to be a contributing cause to Alzheimer's. They specifically mentioned Zanax and Valium in the episode.
Eduardo
Ultrasoud to open the BBB is a bit difficult, using just ultrasound for doing a stimulation of the brain is more easy to do, is like TDCS or rTMS. Edavarone looks promising, I think that combining it with Methylene blue and Curcumin could be a good approach to stop Alzheimer in the first stage of the disease. So if you have a person that has the first symptoms of the disease, search for how to use methylene blue, buy some liposomal curcumin and try to get some edavarone.
Nessa3
That's where so many nootropics come from. There's no difference between the compounds we discuss here and some of the drugs marketed now or in the future for cognitive decline. Nobody can get this much funding to research new drugs just for fun for people who have the knowledge and can afford them. Galantamine and donepezil are the first two that come to mind.

Although the same word is used for both AFAIK, there is a distinction between drugs that work in healthy people and those that work in people suffering from Alzheimer's and related diseases.
Emily
There's also a big difference between normal age related cognitive decline and Alzheimer's/dementia - pretty much everyone will experience at least some cognitive decline because that's just what happens when you age. A claim that something prevents cognitive decline doesn't necessarily mean it prevents cognitive decline associated with Alzheimer's. There are theoretically things you can do to slow the onset of it but there's yet to be a proven way to completely halt, or reverse it (as fair as I'm aware). Plus, since the cause of Alzheimer's is unknown in about 95% of cases, it hinders scientists ability to slow, prevent, or cure.

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