Most nootropic enthusiasts are lazy so I'll keep it simple. I'm a bio-hacker so it is essential for me to look at all aspects of life for health and happiness but there are a many supplements that can temporary relieve and some even slowly or slightly fix some symptoms of depression such as anhedonia, lethargy, low energy, willpower loss etc. I could be wrong on many of the ideas that I share but these are the things, supplements, nootropic stacks that I have researched and tried and worked for me. There are limit on what I can brain dump on here, so anything that you need elaboration on, just google research yourself. But I'l try to answer any question if you ask me. Take what you can from me and apply it to yourself. Before I get into any supplements, my number one advice is to completely cut out sugar. If your brain is fucked, especially with depression, you're not meant to have sugar, ever. You don't even eat fruits anymore. And no more alcohol. Do everything you can to keep your blood sugar balanced. But that all depends on how much you care to get better or how badly depression affects you. Your gut health is most important in your mood. 90% of serotonin is produced in your gut. If you have busted gut then you also have busted brain. Think of all the garbage you are eating. Gluten, dairy, vegetable oils, sugar, etc. Now let's get to supplements. Vitamin B12 and Folate will help your body synthesize neurotransmitters. You can take all the Tyrosine but if your methylation is blocked then your brain will not make the happy chemicals. Don't let me confuse you if you don't know what methylation is. Just remember it's one of the most important mechanism in your body and it chooses which genes are utilized and it basically makes up your personality. B12 and folate will help release the partially blocked methylation. I will mention what the best forms of the supplements are to take . You should be able to find them at health food stores. B12 in a form of Methylcobalamin or look on reddit sales. I take 5mg daily sublingual. Dissolve in your cheeks for at least an hour. The first time I did this I felt very energized, but anxious. It takes time to get used to because you are releasing your methylation. Folate. Do not take folic acid. You can just take them with water. L-Tyrosine: Amino acid used as precursor to dopamine. Phenylalanine: Amino acid that converts in to Tyrosine. Take the two together and it can be very helpful for depression. I used to take these quite often and had success with them. Or just either one is just fine. I personally like Phenylalanine but it's up to you. L-Tyrosine works quicker. 5HTP: Precursor to serotonin. L-Tryptophan: Amino acid that converts into 5HTP. Don't take both. Serotonin is great, seriously. Everything is gonna be okay. Emergency anti-depressants ADHD stimulants (dexedrine, adderal, or ritalin): If your brain is a permanently dopamine deficient broken factory, these supplements will make you feel like a superman for a day, you can forget about ahnedonia or depression. But prescription only. Or bum some off of your friends if you really need to vanquish the depression for a day. Modafinil: This is my personal favourite emergency drug. Some people take it daily. One of the lowest toxicity of all pharmaceuticals. If you are genetically fit for this nootropic/medication, it can make you a God with strongest willpower. It's like being constantly injected with low dose of cocaine, but without experiencing unpleasant side effects. Unfortunately this is not my case, but it does enhance my mood and cut my excessive daytime sleepiness. Extremely difficult to obtain. I ordered SunModalert and give some to my friends for trial and they love it. They are prescription drugs and only modafinil is considered a nootropic. But the ADHD stimulants are easier to obtain from the doctors. Super anti-depressant Tianeptine: I think this is a remarkable anti-depressant. Instead of the conventional SSRI (inhibitor), Tianeptine is a SSRE (enhancer), or so it is considered… I've tried SSRI before and it made me feel pretty zombie like and did not enhance my mood at all. Remember, SSRI works for half the people and relieves half the symptoms. Tianeptine worked on the first day and it has been a magic. For my usual depressed brain, it has been a long time since I was self-amused, free from outcome, and just laughing like I'm high on life. This nootropic is for serotonin and not for dopamine so it will not necessary give you motivation but really good for anxious feeling depression. Lowest toxicity of all anti-depressants, but banned in North America. God bless. I ordered mine from powdercity. Powdercity is my favourite site to order nootropics from. Cheapest, high quality and swift delivery. Thyroid and depression I've not realized the importance of thyroid until I took my first two drops of liquid iodine. I was so revved up that I only slept about 10 hours that week. Iodine is an essential nutrient that supports the production of thyroid hormones. Of course, now that I am replenished, I do not sleep 10 hours per week. Recently I've learnt the next level importance of thyroid health. Coconut oil……. WTF….. So I have been keeping track of my mood, energy, serenity, and performance and the supplements that I take. For about a week I had unbearable anxiety and constant panic attacks, and had it last for another week I would have jumped out of my balcony. Later I realized that the coconut oil was causing this. I've done my research and found out that coconut oil also supports the thyroid function. I suffer from chronic fatigue syndrome and it leaves me sitting or laying down all day, and not do anything unless it involves great mental stimulation. Since taking coconut oil, I wake up and clean my place, read books, and go for bike rides and I run endlessly. I go outside in a T-shirt while everybody is wearing winter coat. I just adjust my dosage so that I get the energy and motivation benefits from the coconut oil without the panic attack. It's not going to work for everyone, but coconut oil is good for you anyways. I would take 5 tablespoons if I can. Moral of the story, don't underestimate your thyroid. Take good care of it. Phenibut: Potent anti-anxiety, mood enhancing, and socially lubricating nootropic. Phenibut is GABA that is able to cross the blood brain barrier so it works very well in inhibiting your over-firing neurons like norepinephrine. It works well as alcohol alternative, or benzo alternative. Sulbutiamine: Synthetic vitamine B1 that crosses the blood brain barrier. It basically dumps whole a lot of dopamine in your brain in 5 hours so you will feel great. It is also a great social lubricant. After the effects diminish, you feel tired and low, but this nootropic has kind of semi-permanent benefits as your brain is dopamine depleted, the compensatory mechanism makes the dopamine receptors more sensitive. This is great because it beats the dopamine deficiency and makes you feel better with just little amount of dopamine. Rhodiola: Not sure if it's placebo, but I think this enhances my mental energy. Just something to add on. It could be very useful to you. Omega 3 (DHA): This is a very good anti-depressant and ADHD relief. I used to have problems with connecting my imagination to my words and since taking omega 3 it has minimized that. If you mix it with Alpha GPC, it helps the body to make uridine which is a potet antidepressant. Okay. I've written a long thread and I am finally tired. I hope this is helpful to whoever that reads. Don't take my word for everything. Do your own research. Don't rely on nootropics too much. I thought that my depression was invincible so I worked so hard to make my life exciting to relieve my depression. You can do the same, little by little. Develop yourself. Enjoy the present moment. Stop playing video games and jacking off to porn. Get in upward spiral. If you had to die tomorrow the last thing you will think about is nootropics.