Serious inquiry...
Someone close to me is tapering off opiates. They are scared of the withdrawals and fear they might relapse. I told them that there are products that might help.
Can you suggest to me some nootropics that would help best to relieve withdrawal symptoms??
Caleb
1) Agmatine prevents withdrawals, will strengthen his high & lower his tolerance. Use 250mg 3-4 times daily. 2) Memantine will lower his tolerance synergistically with Agmatine, they both help curb cravings 3) Salvia Divinorum has broad anti-addictive properties & can reset your reward system with heavy drug abuse.
Olav
Which opioid is he coming off? Introduce ultralow dose naltrexone, then do a kratom taper (unless he is coming off sometging really heavy like oxycodone or methadone, then might do buprenorphine first) Look up Heantos, Chinese herbs remove like 60% of symptoms. Iboga is also very helpful, I can hook you up with doctors and treatment providers. Loperamide is also helpful for mild withdrawals. You can PM me if you like, I am active in the ibogaine community and Dr Howard Lotsof was my friend. Classic nootropics are not of much use in the acute withdrawal phase. You can introduce milder NMDA antagonist but the effects of agmatine or memantine will not be dramatic when tolerance has already developed. Ibogaine though is a whole different story. Research also indicates Ashwagandha is useful. Megadoses of C-vitamins too.
Igor
Kratom is not very hard how eroine, i read that now use iboga kambo frog and heantos and why not some nootropics as phenibut or other
Olav
And add in some microdosing of iboga and naltrexone, all your Post Abstinence Withdrawals will slowly vanish, I have seen manysuccess storey on reddit. If you take every kratom dosage with a microdose of naltrexone, the withdrawals getting of will be very mild. "It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt (“cold turkey”), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome."
Caleb
I guess your best option would be to get a hold of: Naltrexone, Iboga, Agmatine, Memantine, Kratom & Myrrh and just cover all grounds.
Vito
Just a warning... there are people here telling you to try naltrexone. These people are woefully misinformed and have obviously never taken it. It's similar to narcan. both are used to reverse the effects of opiates either during an overdose (in the case of narcan) or as a maintenance program to consistently block the effects of opiates during an attempt at abstinence. Again... I do not recommend naltrexone, unless of course, you are trying to torture the person attempting to withdrawal. Thats not a joke... an opiate addict injected with a shot of narcan is immediately thrown into full intensity withdrawals.
there are some misguided people who have a strange idea that there is some nobility in that kind of pain, and that one needs to suffer to get truly sober. Unfortunately, studies show that the more times a person goes through withdrawal, and the more intense that withdrawal is, the MORE likely they are to relapse. So LESSENING the intensity of withdrawal is the best way to raise the likelihood that a person will not relapse. The best way to do that is a slow taper using maintenance opioids.
Drew
Go to reddit, no go to a doctor. That's the only way it happens for 97% of us. about 3 % of of opiate addicts recover without any maintenance treatment. Most opiate addicts, myself included will only ever feel normal while using opiates. I've been on suboxone for 2 1/2 years and haven't used drugs since then. I may be biased, as seeing so many friends I've gotten close to in rehabs and halfway houses die largely due to maintenance therapies not being available and even looked down upon. Kratom is the only thing mentioned that could help the acute withdrawal, but depending on tolerance and what drug was used. It It's hydrocodone, codeine or something of that nature Kratom might be more suitable. If it's a heroin addict, hydromorphone or high dose oxycodone, subutex would be most effective. Most other things that were listed could be very helpful after acute withdrawal subsides, but hardcore opiate withdrawal is pure torture. All Doctor's aren't bad, you just have to find one who genuinely wants to help you.
The goal is to quit using drugs and destroying your life, whatever works for someone is a good thing. I'm a proponent of subutex, as it's been proven to be effective and has helped me and others tremendously. Some of those things could be effective, but probably not in the short term. Calling maintenance therapy pathetic and lazy is pretty ignorant of addiction itself. It's that attitude that keeps American recovery rates so low compared to the 30, 40 percent rates of European countries.
John
I actually got off Heroin by using meth for the withdrawals. This was in the year 2001 probably. I went to multiple Hospitals but I would always leave the next day. I couldnt handle the withdrawals especially the restlessness was unbearable. The meth worked but that's all I knew about back then. I never went back to using Heroin. True story.
If I had to do it again. I would try to go to a detox with subutex. They didn't have that stuff back then, and only had methadone. Methadone didn't work for me, probably because they would only offer up to a certain dose. I heard miracle things from addicts about subutex that it completely takes away the withdrawls. If I couldn't get into a detox and had to do it again at home, I would try some of these alternative methods at home. I would also have some artane handy for any restelessness, that was the worse for me personally.
Sarah
What I use is the following: immodium tabs for actual withdrawal, b12, b6, N-acetyl tyrosine, piraractam, mephredone occasionally
Tom
Phenibut for the first 3 days of withdrawal maybe, bacopa, ashwagandha, l theanine, kava, valerian, chamomile, Kratom, Imodium, and benadryl. Make tea out of the herbs and Kratom, take capsules of the nootropics, and take a couple Imodium 2-3 times a day to keep the squirts at bay, benadryl keeps the itching, runny nose, watery eyes at bay, the herbs all work on the gaba receptors for relaxation, the nootropics help cope with he stress of withdrawals and the Kratom because of its ability to get folks through withdrawals.
Audrey
I used kratom, l-theanine, b12, fish oil and a multi. It works great for me! The kratom is a necessity!
Sarah
What I use is the following: immodium tabs for actual withdrawal, b12, b6, N-acetyl tyrosine, piraractam, mephredone occasionally
Caleb
1) Agmatine prevents withdrawals, will strengthen his high & lower his tolerance. Use 250mg 3-4 times daily. 2) Memantine will lower his tolerance synergistically with Agmatine, they both help curb cravings 3) Salvia Divinorum has broad anti-addictive properties & can reset your reward system with heavy drug abuse.
Josh
would definetly go with kratom then taper off that
Olav
Introduce ultralow dose naltrexone, then do a kratom taper (unless sometging really heavy like oxycodone or methadone, then might do buprenorphine first) Look up Heantos, Chinese herbs remove like 60% of symptoms. Iboga is also very helpful, I can hook you up with doctors and treatment providers. Loperamide is also helpful for mild withdrawals. You can PM me if you like, I am active in the ibogaine community and Dr Howard Lotsof was my friend. Classic nootropics are not of much use in the acute withdrawal phase. You can introduce milder NMDA antagonist but the effects of agmatine or memantine will not be dramatic when tolerance has already developed. Ibogaine though is a whole different story. Research also indicates Ashwagandha is useful. Megadoses of C-vitamins too.
Caleb
I guess your best option would be to get a hold of: Naltrexone, Iboga, Agmatine, Memantine, Kratom & Myrrh and just cover all grounds.
Caleb
Naltrexone microdoses (100-250 micrograms) potentiate opiate analgesia & completely (or nearly) block their tolerance accumulation. Sorry I forgot the clarification
John
I actually got off Heroin by using meth for the withdrawals. This was in the year 2001 probably. I went to multiple Hospitals but I would always leave the next day. I couldnt handle the withdrawals especially the restlessness was unbearable. The meth worked but that's all I knew about back then. I never went back to using Heroin. True story.
If I had to do it again. I would try to go to a detox with subutex. They didn't have that stuff back then, and only had methadone. Methadone didn't work for me, probably because they would only offer up to a certain dose. I heard miracle things from addicts about subutex that it completely takes away the withdrawls. If I couldn't get into a detox and had to do it again at home, I would try some of these alternative methods at home. I would also have some artane handy for any restelessness, that was the worse for me personally.
Joseph
Be careful with phenibut and tianpetiene. Both are addictive, tian can basically give you an opiate addiction, and phenibut can near permanently mess with your GABA receptors. Im sure there are a few more, but Im unaware
Francisco
A true nootropic has neither addiction nor withdrawal. And virtually no side effects. Want to rebuild damage due to substance abuse. Semax, n-acetyl semax is the answer.
Marissa
If something is a true nootropic by the definition of Nootropic it won't have tolerance or withdrawal issues. Just the opposite, actually.

Here's some homework for you that might help:
Agmatine helps reduce tolerance to many things like opioids and and anything that works on GABA receptors. Amazing stuff!

Bacopa Monnieri and Fasoracetam (in conjunction with a choline source) helps repair receptors after continued use of opioids and GABA receptor inhibitors.
Caleb
The perfect stack would be Agmatine, Memantine, Magnesium, Huperzine A. Best for Opiate tolerance/addiction (in order of effectiveness. You could cold turkey any opiate with large doses of Agmatine and Syrian Rue 2-3 days. It's due to the magical yet illusive I2 receptor.
Substitute Kratom for Suboxone, then taper down until low tolerance. You don't even need to stop using Kratom like 1-2x a week is fine, more if you cycle strains and use the four tolerance reducers
Jesper
Agmatine, frankicense, myrrh, black pepper, lecithin, coconut oil, ltheanine, magnesium glycinate, cardiovascular exercise to reduce withdrawals

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