Some of you may have heard that long term use of benzos, drugs like Xanax, clonazepam, etc, have recently been implicated in dementia and Alzheimer's. I've also heard they lead to mitochondrial degradation in general. What's more, they are addictive and have severe withdrawal syndromes. I've been on clonazepam 1mg about 20 years. I'm trying to get off it and have found aniracetam somewhat helpful. My question is whether Phenibut and baclofen are helpful with withdrawal or whether you would just end up being addicted to another GABA type drug. Also, does baclofen improve sleep quality? Personal experiences or research links most appreciated.
The best way to come off of benzos is extremely slow titration. Even then you're gonna have rebound anxiety and muscle cramps. Potassium will help with the cramps and CBD with the anxiety but it's gonna eventually come down to enduring it till it's over.
I would keep taking the bacopa as suggested but also for probable panic attacks I would take long acting propranolol as in half indrel sustained dose at about 80mg to 160mg per day at leat for a few weeks. You could also consider Relora to reduce cortisol which may become a problem. Stress is also linked to cortisol as well as low Gaba
Replacement therapy probably isnt needed as you havent increased dosage so tolerance rebound issues arent as much of an issue as just tapering off.
Memantine could help, not typically used for tapering this class of drugs, but its pretty effective for most people, that just depends on if it helps with the underlying issues at play.
Seen some anecdotal evidence of Huperzine A being useful for withdrawals as well, possibly due to the NGF increase, but its pretty awesome overall so getting some of that in your cycle might be worthwhile.
Only other things worth suggesting that come to mind are Magnesium (anything other than Oxide which stays in the gut) and Picamilon (doses under 300mg are non-stimulating) with Theanine and maybe some Taurine. You could mix up those in ratio and have it multiple times throughout your day as you taper off and they are all very safe without causing any rebound. For sleep quality get some Glycine (3-5g dosage minimum), it wont sedate you to sleep but it definitely improves quality and minimizes the number of times you wake during the night.
Good luck
flumezanil, in simple terms: a reboot for gaba a systems. Helps with withdrawal but may help to reverse some degree of ultra-long lasting tolerance which could link to the neurodegenerative diseases mentioned due to inability to control excitability as before, thus fall prey to excitotoxicities! Flumezanil is the benzo antidote essentially, both for acute overdose and chronic changes
My experience with phenibut is ive been using since Dec. thrice a week and haven't experienced any withdrawals it helps me with social anxiety...and PTSD i have I'm glad their is such a compound ..but with with that being said respect the drug and it will respect you....i take 2.5grams twice a week with no issues ..only negative i get from it is i get kinda lazy on the 4th day without it :P so i take modafinil that i'm prescribed to combat this ....
twt clomid while on trt what time of day should i take clomid
The absolute best thing to get off Benzos (And Alcohol as well) is TIANEPTINE. No matter what form (Sodium, Sulfate, or Acid; The latter two last longer). Absolutely no withdrawal symptoms and also helps in its own way in various areas.
However, typically to achieve these effects, the dose needs to be at least 100 mg rather than the "therapeutic" miniscule dose of 12.5 mg.
It can become quite expensive, especially if your doses start to escalate. Try to avoid that at all costs. Find a dose that works (relieves withdrawals), and stick to it. It's a wonder drug if you're strict with yourself and avoid recreational use. 5 grams are typically ~$30-40 for the quick-onset, but short-lasting Tianeptine Sodium. Tianeptine Sulfate is more expensive (~$50-60 for 5 grams), but comes on gradually and lasts about 3x longer. Tianeptine Acid (~$26.88 for 5 grams) is my favorite. It's the cheapest and lasts about as long as the Sulfate, maybe longer. The Free Acid form requires a higher dosage, but is much easier to handle than the hygroscopic Sodium form and the price overall is still better. Google Tianeptine Acid and you'll find it.

Phenibut, on the other hand, is also a really good choice for Clonazepam withdrawal. I can't say I've tried it long-term, but for the little while I tried it, withdrawal symptoms were relieved to a fairly significant degree. I was taking 2-3 grams at the time, but it helps with insomnia, anxiety, and generally kind of chills you out. Plus it makes music sound AMAZING.

Anyway, from my experience, Tianeptine definitely works and so does Phenibut, however to a fairly lower degree.

Just tried it for the first time today! I'm physically dependent on xanax taken as prescribed. You don't have to "like" it to develop a dependency. I don't feel like Phenibut is going to tempt me into compulsion but I used to feel the same way about benzos also. Phenibut was very effective and long lasting for me today! I'm glad to have it around in the case something happens to my monthly allotment of xanax. Part of my prescription was stolen this month. FR not lyin. I wouldn't use Phenibut more than twice a week no matter what because I don't want to downregulate my gaba B receptors in addition to the damage already done to my gaba A. I can't imagine being dependent on both. That would be hell! You would probably be better off ordering etizolam or something like that. It works on gaba A and not B. Don't quote me but I'm fairly certain.

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