For those of you who have taken wellbutrin for an extended period of time (>3 months) did you notice any persistent brain fog /lapses in memory?
Wellbutrin (and its main metabolites) are non-competitive Nicotinic acetylcholine receptor (nAChR) antagonists so they target the same receptor that nicotine agonizes, hence it is also prescribed as a smoking cessation aid. But nACh is important for memory, which is why some people use nicotine as a nootropic. Since wellbutrin is a non-competitive nAChR antagonist, this means no amount of agonist can acheive maximum response in the receptor. So basically, my idea of taking nicotine gum while on wellbutrin won't work since it would block most of the effect of the nicotine.
So the only possibility is that you would have to endure a period of time until/if the nACh are upregulated. To reformulate my question, how long does it take for upregulation to occur, if it happens at all?